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Women Must Know about Hyperandrogenism

Hyperandrogenism is a condition in which excessive levels of androgen hormones in a woman's body. Normally, women have only a small amount of androgen. Various health problems can arise if the amount of androgen hormone levels in a woman's body are excessive.

Androgen or testosterone is produced in both male and female bodies. It's just that the amount of this hormone is normally more in men.

In women, androgens are produced by the adrenal glands, ovaries, and fat cells. Together with other hormones, the androgen hormone is responsible for regulating and maintaining various bodily functions, including the reproductive organs and bones. Androgen hormones are also responsible for regulating libido.

Therefore, various health problems can arise when androgen hormone levels exceed normal limits in a woman's body.

Clinical Manifestations of Hyperandrogenism in women

These following are some clinical symptoms that can arise due to androgen levels are too high in women:

  • Increased muscle mass
  • Breast size shrinks
  • Enlarged clitoris
  • Growing dense hair on the face and various parts of the body
  • Hair loss or baldness
  • Severe acne
  • The voice sounds heavier.
  • Menstruation is not smooth.
  • Decreased libido

Some of these symptoms can make a woman feel less confident. Not only these things, but hyperandrogenic are also at risk of causing fertility problems in women. However, women who have hyperandrogenism can still become pregnant if they have regular coitus without contraception.

Some studies also state that women who have hyperandrogenism are more at risk of experiencing psychological disorders, such as mood swings, depression, and anxiety disorders.

ETIOLOGY

What causes hyperandrogenism?

Several medical conditions can cause a woman to experience hyperandrogenism:
  • Ovarian diseases, such as polycystic ovarian syndrome and ovarian cancer
  • Disorders of the adrenal glands, such as congenital adrenal hyperplasia and adrenal gland tumors
  • Diseases that attack the brain's pituitary gland include Cushing's syndrome, acromegaly, and prolactinoma.
  • Side effects of certain drugs, such as anabolic steroids, testosterone hormone therapy, and insulin injections
  • Insulin resistance
  • obesity 
  • Having a family history of hyperandrogenism.

TREATMENT and THERAPY

How to Treat Hyperandrogenism in Women?

Hyperandrogenism therapy in women must be adjusted according to the causes. Therefore, women who suffer from hyperandrogenism need to see a doctor.

To establish the diagnosis and determine the cause of hyperandrogenic experienced by patients, the doctor will conduct a thorough examination, including blood tests, to determine levels of androgen hormones.

After a patient is indicated suffering from hyperandrogenic, doctors will usually advise patients to change lifestyles, for example, by following a healthy diet and regular exercise to achieve ideal body weight.

Hyperandrogenism can be treated by administering drugs, including:

a. Antiandrogen drugs
Antiandrogen drugs are types of drugs that can reduce levels of androgen hormones in the body. There are several types of antiandrogen drugs, namely spironolactone, flutamide, and cyproterone acetate (CPA).

b. Contraceptive pills that contain antiandrogens
For women with hyperandrogenic conditions who are not planning to become pregnant, hormonal contraception can be an option to reduce androgen levels in the body.

Many types of hormonal contraception can be used in treating hyperandrogenism. One of them is a combined contraceptive pill that contains estrogen and progesterone. Also, hormonal contraception contains progesterone Levonorgestrel, Norgestimate, Desogestrel, Drospirenone, Siproteron acetate (CPA).

To reduce excess androgen levels, the recommended type of hormonal contraception is hormonal contraception, which contains a combination of Etiniletsradiol and Siproteron acetate (CPA).

As an antiandrogen, Siproteron acetate works by decreasing the levels of free androgen hormones, reducing oil production in the skin, and preventing the emergence of skin problems, such as acne, or the growth of thick hair on the face and some areas of the body.

What happens if hyperandrogenism is untreated? 

Untreated hyperandrogenism can cause more serious disorders. If not appropriately treated, hyperandrogenism can cause obesity, diabetes, and difficulty getting pregnant.

Some studies also show that women with menopausal hyperandrogenic conditions will be more susceptible to cardiovascular diseases, such as high blood pressure, heart disease, and stroke.

Therefore, if there are symptoms of hyperandrogenism, you should immediately consult the doctor. The sooner the treatment is given, the less likely the occurrence of complications that can be dangerous.

References
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